If you have good amount of luggage, then you can dump it in Leh hotel while you visit Nubra, Pangong Tso etc and come back to hotel. If you plan to halt at Karu/Upshi just to avoid the 40kms of good road travel, then you will have to travel with all the luggage to Pangong Tso via Chang La, which is quite tough.
I toured Leh on GS150R with my wife as pillion, saddle bags, tank bag and 2 backpacks. GS is very capable, and she didn't need any fingering with the jet etc. If your bike runs well in Jammu and Srinagar, it will run well in Leh. There is a good mechanic at Ramban ( some 15 kms after patnitop), you can get any problems rectified. All the best

EDIT: You may want to check your starting and ending points. 'BOMAY 2 Ladhak'? How can one misspell both the names at the same time?!



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